Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri

被引：47

作者：

Ankli, A

Heilmann, J

Heinrich, M

Sticher, O

机构：

[1] Swiss Fed Inst Technol, ETH Zurich, Dept Appl Biosci, Inst Pharmaceut Sci, CH-8057 Zurich, Switzerland

[2] Univ London, Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

来源：

PHYTOCHEMISTRY | 2000年 / 54卷 / 05期

关键词：

Crossopetalum gaumeri; Celastraceae; cardenolides; triterpenes; diterpene; cytotoxic activity; antibacterial activity; Yucatec Maya; traditional medicine;

D O I：

10.1016/S0031-9422(00)00144-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From the methanol extract of the roots of Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3 beta-O-beta-6-deoxyguloside (2), 19-hydroxy-sarmentogenin-3 beta-O-beta-6-deoxyguloside (4), sarmentogenin-3 beta-O-[alpha-allosyl-(1 --> 4)-beta-6-deoxyalloside] (5), and securigenin-3 beta-O-[alpha-allosyl-(1 --> 4)-beta-6-deoxyalloside] (6) were isolated. The dichloromethane extract afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene (7) as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-oic acid methylester (11). The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：531 / 537

页数：7

共 25 条

[1]

Ankli A, 1999, ECON BOT, V53, P144, DOI 10.1007/BF02866493

[2]

ANKLI A, UNPUB J EHTNOPHARMAC

[3]

BABBERLY DJ, 1987, PLANT BOOK PORTABLE

[4]

BRUNING R, 1978, PHYTOCHEMISTRY, V17, P1821, DOI 10.1016/S0031-9422(00)88719-1