An Activity-Based Imaging Probe for the Integral Membrane Hydrolase KIAA1363

被引：44

作者：

Chang, Jae Won ^{[1
]}

Moellering, Raymond E. ^{[1
]}

Cravatt, Benjamin F. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ABPP; fluorescence imaging; fluorescent probes; KIAA1363; serine hydrolases; FUNCTIONAL PROTEOMIC ANALYSIS; COMPLEX PROTEOMES; ENZYME;

D O I：

10.1002/anie.201107236

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Profiling enzyme activities: A selective, activity-based imaging probe is described for the integral membrane hydrolase KIAA1363 and used to determine the subcellular localization and half-life of this enzyme in human cancer cells (see picture). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：966 / 970

页数：5

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