An axially chiral phosphine ligand based on restricted rotation in N-arylimides

被引：38

作者：

Chen, YZ ^{[1
]}

Smith, MD ^{[1
]}

Shimizu, KD ^{[1
]}

机构：

[1] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(01)01482-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Described is the preparation, resolution, and absolute configuration of a new axially chiral monodentate phosphine ligand. The chirality of the ligand is derived from restricted rotation about a central N-imide-C-aryl bond, resulting in enantiomeric atropisomers that are stable and separable up to > 120 degreesC. Finally, the ability of the new axially chiral phosphine ligand is demonstrated in a Pd-catalyzed allylic alkylation reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7185 / 7187

页数：3

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