The EDEM and Yos9p families of lectin-like ERAD factors

被引：64

作者：

Kanehara, Kazue

Kawaguchi, Shinichi

Ng, Davis T. W. ^{[1
]}

机构：

[1] Natl Univ Singapore, Temasek Life Sci Lab, Singapore 117604, Singapore

[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117604, Singapore

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2007年 / 18卷 / 06期

基金：

日本学术振兴会;

关键词：

ER-associate degradation; ER quality control; ERAD; EDEM; Htm1p; Yos9p; misfolded proteins; lectin; N-linked glycosylation;

D O I：

10.1016/j.semcdb.2007.09.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protein quality control pathways monitor the folding of newly synthesized proteins throughout the cell. Irreversibly misfolded proteins are sorted and degraded to neutralize their potential toxicity. In the secretory pathway, multiple strategies have evolved to test the wide diversity of molecules that traffic through the endoplasmic reticulum. The organelle has adapted the use of N-linked glycans to signal protein folding states. The signals are read by the EDEM and Yos9 protein families that take substrates out of folding cycles for degradation. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：743 / 750

页数：8

共 66 条

[21] DER7, encoding α-glucosidase I is essential for degradation of malfolded glycoproteins of the endoplasmic reticulum [J].