The role of regulatory T cells in chronic and acute viral infections

被引：59

作者：

Keynan, Yoav ^{[1
]}

Card, Catherine M. ^{[1
]}

McLaren, Paul J. ^{[1
]}

Dawood, Magdy R. ^{[1
,4
]}

Kasper, Ken ^{[1
,3
]}

Fowke, Keith R. ^{[1
,2
,5
]}

机构：

[1] Univ Manitoba, Dept Med Microbiol, Lab Viral Immunol, Winnipeg, MB R3E 0W3, Canada

[2] Univ Manitoba, Dept Community Hlth Sci, Winnipeg, MB R3E 0W3, Canada

[3] Univ Manitoba, Dept Med, Winnipeg, MB R3E 0W3, Canada

[4] Cadham Prov Lab, Winnipeg, MB, Canada

[5] Univ Nairobi, Dept Med Microbiol, Nairobi, Kenya

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 46卷 / 07期

关键词：

D O I：

10.1086/529379

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T cells, a subset of CD4(+) T lymphocytes, play a pivotal role in the maintenance of the balance between the tissue-damaging and protective effects of the immune response. These cells have immunosuppressive function and have been intensely studied in the context of autoimmunity, cancer, allergies, asthma, and infectious diseases. Their role in chronic and persistent viral infections is well appreciated. In acute viral infections, the function of these cells is still unclear. The host and pathogen factors that control the generation and activity of regulatory T cells and the role of these cells in modulating expansion, contraction, and development of immune memory in acute respiratory virus infection need to be further elucidated.

引用

页码：1046 / 1052

页数：7

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