Treatment of medullary thyroid carcinoma: an update

被引：64

作者：

Orlandi, F ^{[1
]}

Caraci, P ^{[1
]}

Mussa, A ^{[1
]}

Saggiorato, E ^{[1
]}

Pancani, G ^{[1
]}

Angeli, A ^{[1
]}

机构：

[1] Univ Turin, S Luigi Hosp, Dept Internal Med, Turin, Italy

来源：

关键词：

D O I：

10.1677/erc.0.0080135

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prognosis and treatment effectiveness of medullary thyroid carcinoma (MTC) are largely related to the tumour stage, so that early diagnosis represents an important goal for the management of patients. Recent advances in genetic testing have improved the clinical approach to the familial MTC syndromes. There is general agreement that the primary operation for MTC should obtain the complete removal of the neoplastic tissue in the neck, because any adjuvant treatment has never been proven to be effective. The management of residual/recurrent or metastatic MTC still remains controversial, although a multimodal approach to advanced disease may be of value in palliation or local control of tumour progression. The role of surgery, external radiotherapy, radionuclide therapy and medical treatment, including biological response modifiers and cytotoxic drugs, are reviewed and discussed.

引用

页码：135 / 147

页数：13

共 167 条

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