Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy

被引：49

作者：

Lin, JJ

Salamon, N

Dutton, RA

Lee, AD

Geaga, JA

Hayashi, KM

Toga, AW

Engel, J

Thompson, PM

机构：

[1] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

[2] Univ Calif Los Angeles, Lab Neuroimaging, Brain Mapping Div, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Dept Radiol, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Brain Res Inst, David Geffen Sch Med, Los Angeles, CA 90024 USA

来源：

NEUROLOGY | 2005年 / 65卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000179003.95838.71

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors used surface-based anatomic mapping to detect features of hippocampal anatomy that correlated with surgical outcomes in patients undergoing surgery for mesial temporal lobe epilepsy with hippocampal sclerosis. Compared with a seizure-free group, hippocampal profiles for the non-seizure-free group had greater diffuse ipsilateral atrophy and more region-specific contralateral atrophy in the anterior, lateral hippocampus. These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes.

引用

页码：1094 / 1097

页数：4

共 8 条

[1] Kainic acid-induced dorsal and ventral hippocampal seizures in rats [J].