A simplified template approach towards the synthesis of a potent beta-3 adrenoceptor agonist at the human receptor

被引：9

作者：

Beeley, LJ

Berge, JM

Chapman, H

Dean, DK

Kelly, J

Lowden, K

Kotecha, NR

Morgan, HKA

Rami, HK

Thompson, M

Vong, AKK

Ward, RW

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,EPSOM KT18 5XQ,SURREY,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,HARLOW CM19 5AW,ESSEX,ENGLAND

[3] SMITHKLINE BEECHAM PHARMACEUT,DEPT PHARMACOL,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(96)00603-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simplified template approach was used to delineate the structural requirements for high potency and intrinsic activity of aryloxypropanolamines as agonists at the human beta-3 adrenoceptor. The information generated was used to prepare selective beta-3 adrenoceptor agonists. (C) 1997, Elsevier Science Ltd.

引用

页码：219 / 224

页数：6

共 15 条

[1] ATYPICAL BETA-ADRENOCEPTOR ON BROWN ADIPOCYTES AS TARGET FOR ANTI-OBESITY DRUGS [J].