Toll-like, receptor 8-mediated reversal of CD4+ regulatory T cell function

被引：614

作者：

Peng, GY

Guo, Z

Kiniwa, Y

Voo, KS

Peng, WY

Fu, TH

Wang, DY

Li, YC

Wang, HY

Wang, RF ^{[1
]}

机构：

[1] Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA

来源：

SCIENCE | 2005年 / 309卷 / 5739期

关键词：

D O I：

10.1126/science.1113401

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD4(+) regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these cells are regulated. We describe a mechanism [inking Toll-like receptor (TLR) 8 signaling to the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse Treg cell function. This effect was independent of dendritic cells but required functional TLR8-MYD88-IRAK4 signaling in Treg cells. Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced antitumor immunity. These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases.

引用

收藏

页码：1380 / 1384

页数：5

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