Role of microRNA-155 in autoimmunity

被引：167

作者：

Leng, Rui-Xue ^{[1
]}

Pan, Hai-Feng ^{[1
]}

Qin, Wei-Zi ^{[1
]}

Chen, Gui-Mei ^{[1
]}

Ye, Dong-Qing ^{[1
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2011年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

MicroRNA-155; Immune cells; Autoimmune diseases; SYSTEMIC-LUPUS-ERYTHEMATOSUS; REGULATORY T-CELLS; RHEUMATOID-ARTHRITIS PATIENTS; INOSITOL PHOSPHATASE SHIP; MULTIPLE-SCLEROSIS; NEGATIVE REGULATOR; DENDRITIC CELLS; HIGH EXPRESSION; NONCODING RNA; MIR-155;

D O I：

10.1016/j.cytogfr.2011.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs (miRNAs) have recently emerged as a major class of gene expression regulators linked to most biological functions. MiR-155 is encoded within a region known as B cell integration cluster (Bic) gene, identified originally as a frequent integration site for the avian leukosis virus. Disregulation of endogenous miR-155 has been implicated in the pathogenesis of human cancers. Recently, aberrant expression of miR-155 was observed in many autoimmune conditions, including rheumatoid arthritis (RA), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). Moreover, functional analysis demonstrated that miR-155 has powerful regulatory potential in a wide variety of immune cells through targeting specific mRNAs. Since pathogenic immune cells play a pivotal role in pathogenesis of human autoimmune diseases, miR-155 might be a versatile therapeutic target. This review will discuss the current understandings for the role of miR-155 in autoimmunity. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：141 / 147

页数：7

共 61 条

[1]

MicroRNAs in Sjogren's syndrome as a prototypic autoimmune disease [J].