Trichinella spiralis:: Modulation of experimental autoimmune encephalomyelitis in DA rats

被引：75

作者：

Gruden-Movsesijan, A. ^{[1
]}

Ilic, N. ^{[1
]}

Mostarica-Stojkovic, M. ^{[2
]}

Stosic-Grujicic, S. ^{[3
]}

Milic, M. ^{[1
]}

Sofronic-Milosavljevic, Lj. ^{[1
]}

机构：

[1] Inst Applicat Nucl Energy, Belgrade 11080, Serbia

[2] Univ Belgrade, Sch Med, Inst Microbiol & Immunol, Belgrade 11000, Serbia

[3] Univ Belgrade, Inst Biol Res Sinisa Stankov, Dept Immunol, Belgrade 11000, Serbia

来源：

EXPERIMENTAL PARASITOLOGY | 2008年 / 118卷 / 04期

关键词：

parasite infection; Trichinella spiralis; T spiralis muscle larvae; L1; stage; new born larvae; experimental autoimmune encephalomyelitis; dark agouti;

D O I：

10.1016/j.exppara.2007.12.003

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学]; 100103 [病原生物学];

摘要：

Helminth infection has a potent systemic immunomodulatory effect on the host immune response, which also affects the development of autoimmune diseases. We investigated the dose-dependent influence of Trichinella spiralis infection on experimental autoimmune encephalomyelitis (EAE). Our model of concomitant T. spiralis infection and EAE demonstrates that established infection of Dark Agouti (DA) rats with the parasite causes amelioration of the clinical course of induced EAE in a dose-dependent way. Infection with T spiralis L1 stage muscle larvae (TSL1) reduced the severity of the autoimmune disease as judged by lower maximal clinical score, cumulative index, duration of illness and degree of mononuclear cell infiltration in T spiralis infected animals compared to control, EAE-induced group. This study provides a valuable model of worm infection to investigate helminth-induced regulatory mechanisms for optimal benefit to the host. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：641 / 647

页数：7

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