Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of Calophyllum teysmannii

被引：54

作者：

Pengsuparp, T

Serit, M

Hughes, SH

Soejarto, DD

Pezzuto, JM

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

[2] CHULALONGKORN UNIV,FAC PHARMACEUT SCI,DEPT BIOCHEM,BANGKOK 10330,THAILAND

[3] UNIV MALAYSIA SARAWAK,FAC RESOURCE SCI & TECHNOL,KOTA SAMARAHAN 94300,SARAWAK,MALAYSIA

[4] NCI,FREDERICK CANC RES & DEV CTR,ABL BASIC RES PROGRAM,FREDERICK,MD 21702

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 09期

关键词：

D O I：

10.1021/np960399y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 mu M. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.

引用

页码：839 / 842

页数：4

共 37 条

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