Sex Differences in Neuroimmunity and Pain

被引：263

作者：

Rosen, Sarah

Ham, Boram

Mogil, Jeffrey S. ^{[1
]}

机构：

[1] McGill Univ, Dept Psychol, 1205 Dr Penfield Ave, Montreal, PQ H3A 1B1, Canada

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2017年 / 95卷 / 1-2期

关键词：

estrogen; IL-1; beta; IL-6; immune system; inflammation; macrophages; microglia; pain; progesterone; sex differences; T cells; testosterone; TNF-alpha; PERIPHERAL-NERVE INJURY; SPINAL-CORD-INJURY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; UNDERLYING NEUROPATHIC PAIN; TRAUMATIC BRAIN-INJURY; CD4(+) T-LYMPHOCYTES; TOLL-LIKE RECEPTOR-4; LAMINA-I NEURONS; INFLAMMATORY MEDIATORS; FEMALE MICE;

D O I：

10.1002/jnr.23831

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Differences in the prevalence of chronic pain in women vs. men are well known, and decades of laboratory experimentation have demonstrated that women are more sensitive to pain than are men. Attention has thus shifted to investigating mechanisms underlying such differences. Recent evidence suggests that neuroimmune modulation of pain may represent an important cause of sex differences. The current Review examines the evidence for gonadal hormone modulation of the immune system, immune system modulation of pain, and interactions that might help to explain sex differences in pain. (C) 2016 Wiley Periodicals, Inc.

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收藏

页码：500 / 508

页数：9

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