Pregnancy under treatment of imatinib and successful labor in a patient with chronic myelogenous leukemia (CML) -: Outcome of discontinuation of imatinib therapy after achieving a molecular remission

被引：44

作者：

Ali, R ^{[1
]}

Özkalemkas, F

Özçelik, T

Özkocaman, V

Ozan, Ü

Kimya, Y

Köksal, N

Gülten, T

Yakut, T

Tunali, A

机构：

[1] Uludag Univ, Sch Med, Dept Internal Med, Div Hematol, Bursa, Turkey

[2] Uludag Univ, Sch Med, Dept Obstet & Gynecol, Bursa, Turkey

[3] Uludag Univ, Sch Med, Dept Pediat, Div Neonatol, Bursa, Turkey

[4] Uludag Univ, Sch Med, Dept Med Genet, Bursa, Turkey

来源：

LEUKEMIA RESEARCH | 2005年 / 29卷 / 08期

关键词：

chronic myelogenous leukemia; pregnancy; imatinib;

D O I：

10.1016/j.leukres.2005.01.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Because of the teratogenicity data in rats, it is recommended that women treated with imatinib should be aware of the potential teratogenicity of imatimb and effective contraception should be used during imatinib therapy to prevent pregnancy. We describe successful pregnancy and delivery, without any congenital anomaly, in a patient with CML under treatment of imatinib. The fetus had been exposed to imatinib for 8 weeks. The patient remained off treatment during gestation and cytogenetic relapse of CML (5 months after discontinuation of imatinib therapy) developed at seventh month of gestation. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：971 / 973

页数：3

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