A fatal case of autoimmune thrombocytopenia with an IgM anti-GPIb/IX following one antigen mismatched unrelated donor bone marrow transplantation

被引：15

作者：

Kottaridis, PD

Rees, H

Smith, G

Garner, SF

Perry, AR

Peniket, AJ

Goldstone, AH

Mackinnon, S

Ouwehand, WH

机构：

[1] UCL Hosp, Dept Haematol, London, England

[2] Univ Cambridge, Dept Haematol, Cambridge CB2 1TN, England

[3] Natl Blood Serv E Anglia, Dept Haematol, Cambridge, England

[4] Natl Inst Biol Stand & Controls, Dept Haematol, Potters Bar EN6 3QG, Herts, England

来源：

BONE MARROW TRANSPLANTATION | 1999年 / 23卷 / 07期

关键词：

allogeneic bone marrow transplantation (BMT); autoimmune thrombocytopenia; platelet glycoprotein Ib/IX;

D O I：

10.1038/sj.bmt.1701651

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report the case of a 32-year-old patient with ALL who developed autoimmune thrombocytopenia 2 months following allogeneic bone marrow transplantation. An IgM autoantibody against the platelet glycoprotein Ib/IX complex was observed. Treatment with high-dose steroids and intravenous immunoglobulin G failed to produce any benefit and the thrombocytopenia led to fatal gastrointestinal haemorrhage. The possible factors contributing to post-allograft thrombocytopenia and potential management strategies are discussed.

引用

页码：739 / 741

页数：3

共 9 条

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