Environmental Isolates of Azole-Resistant Aspergillus fumigatus in Germany

被引：83

作者：

Bader, Oliver ^{[1
]}

Tuennermann, Jana ^{[1
]}

Dudakova, Anna ^{[1
]}

Tangwattanachuleeporn, Marut ^{[1
,2
]}

Weig, Michael ^{[1
]}

Gross, Uwe ^{[1
]}

机构：

[1] Univ Med Ctr Gottingen, Inst Med Microbiol, Gottingen, Germany

[2] Burapha Univ, Fac Allied Hlth Sci, Chon Buri, Thailand

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 07期

关键词：

TR46/Y121F/T289A; MECHANISMS; MUTATION; DENMARK;

D O I：

10.1128/AAC.00100-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Azole antifungal drug resistance in Aspergillus fumigatus is an emerging problem in several parts of the world. Here we investigated the distribution of such strains in soils from Germany. At a general positivity rate of 12%, most prevalently, we found strains with the TR34/L98H and TR46/Y121F/T289A alleles, dispersed along a corridor across northern Germany. Comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of local clinical clusters.

引用

页码：4356 / 4359

页数：4

共 24 条

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