Occurrence of azole-resistant species of Aspergillus in the UK environment

被引：39

作者：

Bromley, Michael J. ^{[1
]}

van Muijlwijk, Guus ^{[2
]}

Fraczek, Marcin G. ^{[1
]}

Robson, Geoff ^{[1
]}

Verweij, Paul E. ^{[3
]}

Denning, David W. ^{[1
]}

Bowyer, Paul ^{[1
]}

机构：

[1] Univ Manchester, Inst Inflammat & Repair, Manchester Fungal Infect Grp, Core Technol Facil, Manchester M13 9NT, Lancs, England

[2] Radboud Univ Nijmegen, NL-6525 ED Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands

来源：

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | 2014年 / 2卷 / 04期

关键词：

Aspergillus; Azole resistance; Neosartorya; Environment; CYP51A GENE; TR/L98H MUTATION; FUMIGATUS; MECHANISM;

D O I：

10.1016/j.jgar.2014.05.004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aim of this study was to survey environmental isolates of Aspergillus resistant to azoles in azole-treated and naive areas to determine whether resistance could be related to azole treatment history. Aspergillus fumigatus was sampled from the centre of a large city and from fields with known azole history. Azole resistance was determined and sequencing was performed to identify strains and mutations in the cyp51A gene. Azole resistance was detected in azole-treated field isolates but not in urban isolates (P = 0.038). In addition, an azole-resistant isolate of Neosartorya fischeri was isolated. These results support the hypothesis that agricultural azole use may lead to resistance in environmental fungi of clinical importance. We report the first environmental UK TR34/L98H isolate of Aspergillus fumigatus. (C) 2014 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

引用

页码：276 / 279

页数：4

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