Lack of de-epoxidation of type B trichothecenes in incubates with human faeces

被引：49

作者：

Eriksen, GS ^{[1
]}

Pettersson, H ^{[1
]}

机构：

[1] Swedish Univ Agr Sci, Dept Anim Nutr & Management, S-75007 Uppsala, Sweden

来源：

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT | 2003年 / 20卷 / 06期

关键词：

deoxynivalenol; nivalenol; metabolism; de-epoxidation; gastrointestinal; humans; faeces;

D O I：

10.1080/0265203031000102573

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The ability of human gastrointestinal organisms to transform the trichothecenes 3-acetyldeoxynivalenol and nivalenol was investigated. Samples of human faeces were incubated under anaerobic conditions for 48 h with the toxins. They were then extracted and analysed for trichothecenes and metabolites. 3-Acetyldeoxynivalenol was metabolized to deoxynivalenol during the incubation period. In contrast to what has been reported for other species such as rats, mice and pigs, no de-epoxidated metabolites were detected in the faecal incubates. The toxicological significance of the difference in the intestinal ability to transform trichothecenes between species is unknown.

引用

页码：579 / 582

页数：4

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