The role of dendritic cells in the development of acute dextran sulfate sodium colitis

被引：121

作者：

Berndt, Bradford E.

Zhang, Min

Chen, Gwo-Hsiao

Huffnagle, Gary B.

Kao, John Y.

机构：

[1] Univ Michigan Hlth Syst, Div Gastroenterol, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan Hlth Syst, Dept Pulm & Crit Care Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan Hlth Syst, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF IMMUNOLOGY | 2007年 / 179卷 / 09期

关键词：

D O I：

10.4049/jimmunol.179.9.6255

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are essential mediators of the host immune response to surrounding microbes. In this study, we investigate the role of DCs in the pathogenesis of a widely used colitis model, dextran sulfate sodium-induced colitis. The effect of dextran sulfate sodium on the production of proinflammatory cytokines and chemokines by bone marrow-derived DCs (BM-DCs) was analyzed. BM-DCs were adoptively transferred into C57BL/6 mice or DCs were ablated using transgenic CD11c-DTR/GFP mice before treatment with 5% dextran sulfate sodium in drinking water. We found that dextran sulfate sodium induced production of proinflammatory cytokines (IL-12 and TNF-alpha) and chemokines (KC, MIP-1 alpha, MIP-2, and MCP-1) by DCs. Adoptive transfer of BM-DCs exacerbated dextran sulfate sodium colitis while ablation of DCs attenuated the colitis. We conclude that DCs are critical in the development of acute dextran sulfate sodium colitis and may serve a key role in immune balance of the gut mucosa.

引用

收藏

页码：6255 / 6262

页数：8

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