1,1-Dibromo-1-alkenes as Valuable Partners in the Copper-Catalyzed Direct Alkynylation of Azoles

被引：77

作者：

Berciano, Beatriz Pacheco ^{[1
,2
]}

Lebrequier, Sabrina ^{[2
]}

Besselievre, Francois ^{[1
,2
]}

Piguel, Sandrine ^{[1
,2
]}

机构：

[1] Univ Paris 11, F-91405 Orsay, France

[2] Ctr Univ, Inst Curie, CNRS, UMR 176, F-91405 Orsay, France

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 18期

关键词：

GACL3-CATALYZED ORTHO-ETHYNYLATION; SONOGASHIRA REACTION; INTERNAL ALKYNES; N-ARYLATION; INDOLE;

D O I：

10.1021/ol1016433

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The copper-catalyzed direct alkynylation of azoles with 1,1-dibromo-1-alkenes as electrophiles is described. These easily accessible substrates are a useful addition to the field of direct alkynylations in an efficient and functional group tolerant reaction to provide a straightforward entry to diverse alkynyl heterocycles.

引用

页码：4038 / 4041

页数：4

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