Palladium-Catalyzed Domino C,N-Coupling/Carbonylation/Suzuki Coupling Reaction: An Efficient Synthesis of 2-Aroyl-/Heteroaroylindoles

被引：105

作者：

Arthuis, Martin

Pontikis, Renee ^{[1
]}

Florent, Jean-Claude

机构：

[1] Ctr Rech, Inst Curie, F-75248 Paris 05, France

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 20期

关键词：

CARBONYLATION REACTIONS; DERIVATIVES; CYCLIZATION; CASCADE; INDOLE; REAGENT; AGENTS;

D O I：

10.1021/ol901875z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient one-pot synthesis of 2-aroylindoles using a domino palladium-catalyzed C,N-coupling/carbonylation/C,C-coupling sequence Is described. The reaction involved easily prepared 2-gem-dibromovinylanilines and boronic acids under carbon monoxide. Optimized reaction conditions allowed the construction of a wide variety of highly functionalized 2-aroyl-/heteroaroylindoles in satisfactory yields.

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页码：4608 / 4611

页数：4

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