Aromatic trifluoromethyldenitration and trifluoromethyldecyanation using trifluoromethyltrimethylsilane

被引:12
作者
Adams, DJ [1 ]
Clark, JH [1 ]
Hansen, LB [1 ]
Sanders, VC [1 ]
Tavener, SJ [1 ]
机构
[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 18期
关键词
D O I
10.1039/a805079a
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Activation of trifluoromethyltrimethylsilane by potassium fluoride in N,N-dimethylacetamide provides a powerful source of trifluoromethide which is capable of substituting aromatic nitro and cyano groups under nucleophilic conditions, albeit in low yield. The trifluoromethide generated in this system is also a potent base which leads to a number of interesting side reactions via deprotonation of the substrate.
引用
收藏
页码:3081 / 3085
页数:5
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