A synthetic route to (+/-)-clavizepine through a dibenzoxepine intermediate

被引：13

作者：

delaFuente, MC

Castedo, L

Dominguez, D

机构：

[1] UNIV SANTIAGO,FAC QUIM,DEPT QUIM ORGAN,SANTIAGO COMPOSTE 15706,SPAIN

[2] CSIC,SECC ALCALOIDES,SANTIAGO COMPOSTE 15706,SPAIN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1996年 / 61卷 / 17期

关键词：

D O I：

10.1021/jo960291n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of (+/-)-clavizepine (1a), based on the dibenzoxepinediol 10 as main intermediate is described. The key step is the contraction of the oxepine ring to give the xanthene-9-carboxyaldehyde 11, on which the nitrogenated ring can be readily assembled.

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页码：5818 / 5822

页数：5

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