Anti-babesial compounds from Curcuma zedoaria

被引：25

作者：

Kasahara, K

Nomura, S

Subecki

Matsuura, H ^{[1
]}

Yamasaki, M

Yamato, O

Maede, Y

Katakura, K

Suzuki, M

Trimurningsih

Chairul

Yoshihara, T

机构：

[1] Hokkaido Univ, Lab Bioorgan Chem, Div Appl Biosci, Grad Sch Agr, Sapporo, Hokkaido 0608589, Japan

[2] Hokkaido Univ, Lab Internal Med, Dept Vet Clin Sci, Grad Sch Vet Med, Sapporo, Hokkaido 0608589, Japan

[3] Gunma Univ, Sch Med, Dept Parasitol, Maebashi, Gumma 371, Japan

[4] Indonesian Inst Sci, Bogor, Indonesia

来源：

PLANTA MEDICA | 2005年 / 71卷 / 05期

关键词：

D O I：

10.1055/s-2005-871216

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Anti-babesial activity was confirmed in an extract of the bark of Curcuma zedoaria. The active ingredients were isolated, and their chemical structures were determined to be zecloalactones A, B, and C based on spectral data. Zedoalactone C is a hitherto unreported compound. The IC50 vales of these active compounds against Babesia gibsoni were compared with a standard drug, diminazene aceturate. The IC50 value of diminazene aceturate was 0.6 mu g/mL, while those of zedoalactones A, B, and C were 16.5,1.6 and 4.2 mu g/mL, respectively.

引用

页码：482 / 484

页数：3

共 9 条

[1] Stereoselective synthesis of 7,11-guaien-8,12-olides from santonin.: Synthesis of podoandin and (+)-zedolactone A [J].