Improvement of contextual memory by S 24795 in aged mice: comparison with memantine

被引:26
作者
Beracochea, Daniel [1 ]
Boucard, Aurelie [1 ]
Trocme-Thibierge, Caryn [2 ]
Morain, Philippe [2 ]
机构
[1] Univ Bordeaux 1, CNIC, CNRS, UMR5228, F-33405 Talence, France
[2] Inst Rech Int Servier, F-92415 Courbevoie, France
关键词
ageing; mice; contextual memory; episodic memory; S; 24795; memantine; nicotinic receptors;
D O I
10.1007/s00213-007-0987-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Results In comparison with 5-month-old mice, 18- to 19-month-old mice exhibited a severe and specific memory impairment in a contextual serial discrimination (CSD) task involving the learning and remembering of two successive spatial discriminations carried out on two distinct floors. This impairment was specific, as spatial memory, simultaneously tested on a simple discrimination (SD) task, was not affected in these aged mice. This deficit was completely reversed by 9-day per os administration of S 24795, a partial agonist of alpha 7 nicotinic receptors, at either 0.3 or 1.0 mg/kg. Memantine, an NMDA receptor antagonist, also had a memory-enhancing effect at a dose of 3.0 mg/kg, but not at 0.3 mg/kg. Conclusions The memory-enhancing effect of S 24795 was due to a strong enhancement of contextual memory as indicated by a decrease in interference rate, whereas memantine enhanced spatial/semantic memory. S 24795 was more effective than memantine and also appears to be more specific to flexible forms of memory, one of the first cognitive domains (i.e. episodic memory) affected in Alzheimer's disease.
引用
收藏
页码:555 / 564
页数:10
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