Preparation of CI-1027 glucuronide: Metabolite of a remarkable lipid-modulating agent

被引：10

作者：

Akin, A ^{[1
]}

Curran, TT ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Pharmaceut Sci, Ann Arbor, MI 48105 USA

来源：

SYNTHETIC COMMUNICATIONS | 2005年 / 35卷 / 12期

关键词：

O-acylglucuronide; enzymatic hydrolysis;

D O I：

10.1081/SCC-200061648

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of the 1 beta-glucuronide of the diacid, CI-1027, is described. The key synthetic steps are coupling of the mono-protected acid with bromoglucuronide, deacetylation, and enzymatic hydrolysis.

引用

页码：1649 / 1661

页数：13

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