Cl-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

被引:211
作者
Allen, LF
Sebolt-Leopold, J
Meyer, MB
机构
[1] Pfizer Global Res & Dev, Dept Clin Dev, Ann Arbor Labs, Ann Arbor, MI 48105 USA
[2] Pfizer Global Res & Dev, Dept Oncol, Ann Arbor Labs, Ann Arbor, MI 48105 USA
[3] Dept Canc Mol Sci, Ann Arbor, MI USA
关键词
D O I
10.1053/j.seminoncol.2003.08.012
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:105 / 116
页数:12
相关论文
共 100 条
  • [81] Schaeffer HJ, 1999, MOL CELL BIOL, V19, P2435
  • [82] Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
    Sebolt-Leopold, JS
    Dudley, DT
    Herrera, R
    Van Becelaere, K
    Wiland, A
    Gowan, RC
    Tecle, H
    Barrett, SD
    Bridges, A
    Przybranowski, S
    Leopold, WR
    Saltiel, AR
    [J]. NATURE MEDICINE, 1999, 5 (07) : 810 - 816
  • [83] Development of anticancer drugs targeting the MAP kinase pathway
    Sebolt-Leopold, JS
    [J]. ONCOGENE, 2000, 19 (56) : 6594 - 6599
  • [84] PROTEIN KINASES .7. THE MAPK SIGNALING CASCADE
    SEGER, R
    KREBS, EG
    [J]. FASEB JOURNAL, 1995, 9 (09) : 726 - 735
  • [85] SEGER R, 1992, J BIOL CHEM, V267, P14373
  • [86] Hyperexpression of mitogen-activated protein kinase in human breast cancer
    Sivaraman, VS
    Wang, HY
    Nuovo, GJ
    Malbon, CC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (07) : 1478 - 1483
  • [87] Spencer VA, 2000, J CELL BIOCHEM, P27
  • [88] Strumberg D, 2002, Int J Clin Pharmacol Ther, V40, P580
  • [89] Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells
    Timms, JF
    White, SL
    O'Hare, MJ
    Waterfield, MD
    [J]. ONCOGENE, 2002, 21 (43) : 6573 - 6586
  • [90] Ras activation in human breast cancer
    von Lintig, FC
    Dreilinger, AD
    Varki, NM
    Wallace, AM
    Casteel, DE
    Boss, GR
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2000, 62 (01) : 51 - 62