Prevalence of Nocturnal Hypoglycemia in Pediatric Type 1 Diabetes: A Pilot Study Using Continuous Glucose Monitoring

被引：19

作者：

Ahmet, Alexandra ^{[1
,2
]}

Dagenais, Simon ^{[3
,4
]}

Barrowman, Nick J. ^{[5
]}

Collins, Catherine J. ^{[5
]}

Lawson, Margaret L. ^{[1
,2
]}

机构：

[1] Univ Ottawa, Childrens Hosp Eastern Ontario, Div Endocrinol & Metab, Ottawa, ON K1H 8L1, Canada

[2] Univ Ottawa, Fac Med, Dept Pediat, Ottawa, ON K1H 8L1, Canada

[3] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON K1H 8L1, Canada

[4] Univ Ottawa, Div Orthopaed Surg, Ottawa, ON K1H 8L1, Canada

[5] Univ Ottawa, Childrens Hosp Eastern Ontario, Res Inst, Ottawa, ON K1H 8L1, Canada

来源：

JOURNAL OF PEDIATRICS | 2011年 / 159卷 / 02期

关键词：

BLOOD-GLUCOSE; RISK-FACTORS; CHILDREN; MELLITUS; SYSTEM; ASSOCIATION; ADOLESCENTS;

D O I：

10.1016/j.jpeds.2011.01.064

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives To determine the prevalence of nocturnal hypoglycemia (NH) in pediatric type 1 diabetes, to compare the prevalence of NH detected by continuous glucose monitoring (CGM) and self-monitored blood glucose (SMBG), and to compare the prevalence of NH using different thresholds. Study design Twenty-five patients wore a continuous glucose monitor for 3 nights and also conducted SMBG. NH was defined with three thresholds: (1) <3.9 mmol/L; (2) <3.3 mmol/L; and (3) <2.9 mmol/L. Results The prevalence of NH with CGM was 68%, 52%, and 48% with the different thresholds. Of the 35 episodes of NH detected by CGM, 25 were not symptomatic and therefore not detected by SMBG. The mean difference in blood glucose between CGM and SMBG was -0.18 mmol/L (P = .35). Conclusions This pilot study suggests that the prevalence of NH in pediatric patients with type 1 diabetes with conventional treatment may be as high as 68%, although this varied according to the method of detection and threshold used. Patients may benefit from CGM to detect asymptomatic NH. (J Pediatr 2011; 159: 297-302).

引用

页码：297 / U385

页数：7

共 19 条

[1] Hypoglycemia prevalence in prepubertal children with type 1 diabetes on standard insulin regimen: Use of continuous glucose monitoring system [J].