Isolation of p-hydroxycinnamaldehyde as an antibacterial substance from the saw fly, Acantholyda parki, S.

被引：32

作者：

Leem, JY

Jeong, IJ

Park, KT

Park, HY

机构：

[1] KIST, Korea Inst Biosci & Biotechnol, Insect Resources Lab, Taejon 305600, South Korea

[2] Kangwon Natl Univ, Coll Agr & Life Sci, Chunchon 200701, South Korea

来源：

FEBS LETTERS | 1999年 / 442卷 / 01期

关键词：

insect immunity; p-hydroxycinnamaldehyde; antibacterial substance; antifungal activity; insect defense molecule; Acantholyda parki S;

D O I：

10.1016/S0014-5793(98)01614-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We purified an antibacterial substance from larvae of the saw fly, Acantholyda parki S,, and identified its molecular structure as p-hydroxycinnamaldehyde. We then synthesized it by reduction of p-hydroxycinnamic acid. The antibacterial activity of the synthetic p-hydroxycinnamaldehyde was equal to that of the authentic substance. This molecule was found to have a broad antibacterial spectrum against not only Gram-negative, but also Gram-positive bacteria. Furthermore, it showed antifungal activity against Candida albicans. We suggest that this substance may play a role in the defense system of this insect. This is the first report of p-hydroscinnamaldehyde of animal origin. (C) 1999 Federation of European Biochemical Societies.

引用

页码：53 / 56

页数：4

共 24 条

[11] Inhibition of protein tyrosine kinase by 5-S-GAD, a novel antibacterial substance from an insect [J].