Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients

被引:13
作者
Anan, Futoshi
Masaki, Takayuki
Umeno, Yoshikazu
Iwao, Tetsu
Yonemochi, Hidetoshi
Eshima, Nobuoki
Saikawa, Tetsunori
Yoshimatsu, Hironobu
机构
[1] Oita Red Cross Hosp, Dept Cardiol, Oita 8700033, Japan
[2] Oita Red Cross Hosp, Dept Endocrinol, Oita 8700033, Japan
[3] Oita Univ, Sch Med, Dept Internal Med 1, Oita 87011, Japan
[4] Oita Univ, Sch Med, Dept Cardiovasc Sci, Oita 87011, Japan
[5] Oita Univ, Sch Med, Dept Biostat, Oita 87011, Japan
关键词
D O I
10.1530/EJE-07-0388
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The elevated level of high-sensitivity C-reactive protein (HSCRP) and aortic stiffness Eire associated with high mortality in type 2 diabetic patients. We tested the hypothesis that the HSCRP correlates with aortic stiffness and insulin resistance in type 2 diabetic patients. Material and methods: The study consisted of 46 Japanese patients with type 2 diabetes and high HSCRP group (0.3-1.0 mg/dl, age: 57 +/- 5 years. mean +/- S.D) and a control group of 5 5 age-matched patients with low HSCRP group (< 0.3 mg/dl, 57 +/- 6 years). Brachiat-ankle pulse wave velocity (BaPWV) was measured by automatic oscillometric method and was used as an index of atherosclerosis. Results: The body mass index (BMI) values (P < 0.05) and waist circumferences (P < 0.0005) and the waist-to-hip ratios (P < 0.05),were higher in the high HSCRP group than in the low HSCRP group. The BaPWV was higher in the high HSCRP group than in the low HSCRP group (P < 0.0001). Fasting plasma glucose (FPG; P < 0.005) and insulin concentrations (P < 0.0001), and the homeostasis model assessment (HOMA) index (P < 0.0001.), were higher in the high HSCRP group than in the low HSCRP group. Multiple regression analysis showed that HSCRP levels were independently predicted by BaPWV and HOMA index. Conclusions: Our results indicate that the elevated level of HSCRP in Japanese patients with type 2 diabetes is characterized by increased aortic stiffness and insulin resistance, and that the BaPWV and HOMA index are independent predictors of HSCRP.
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收藏
页码:311 / 317
页数:7
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