Iridium-mediated β-deuteration of enones

被引：7

作者：

Gibson, JS ^{[1
]}

Herbert, JM ^{[1
]}

机构：

[1] Sanofi Synthelabo Res, Isotope Chem & Metab Synth Dept, Alnwick NE66 2JH, Northd, England

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2003年 / 46卷 / 06期

关键词：

iridium complexes; isotope exchange; vinylic deuteration; orthodeuteration; H-2]-SR46349;

D O I：

10.1002/jlcr.694

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Exposure of captodative enone systems to deuterium in the presence of Crabtree's catalyst (1) results in deuteration at the vinylic site beta- to the ketone carbonyl, as well as at any accessible ortho-position. beta-exchange is also observed during the reduction of ethyl cinnamate (3) catalyzed by 1. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：531 / 537

页数：7

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