Tissue-based stem cells: ABC transporter proteins take centre stage

被引：26

作者：

Alison, MR ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci & Technol, Hammersmith Hosp, Dept Histopathol, London W12 0NN, England

来源：

JOURNAL OF PATHOLOGY | 2003年 / 200卷 / 05期

关键词：

stem cells; side population cells; ABC membrane transporters; liver; cholangiocytes;

D O I：

10.1002/path.1411

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In adult tissues, with the notable exception of the haematopoietic system, the identity of somatic stem cells has often been inferred based on no more evidence than their location. Functional data (clonogenicity) to confirm such an appellation has been absent due to the inability to find appropriate cellular markers with which to isolate live stem cells. Flow cytometry has isolated haematopoietic stem cells based on their ability to exclude Hoechst dye. Named the side population (SP), this phenotype may be a universal marker of stem cells in adult tissues. Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：547 / 550

页数：4