Lupinacidin C, an Inhibitor of Tumor Cell Invasion from Micromonospora lupini

被引：38

作者：

Igarashi, Yasuhiro ^{[1
]}

Yanase, Saeko ^{[1
]}

Sugimoto, Kohei ^{[2
]}

Enomoto, Masaru ^{[2
]}

Miyanaga, Satoshi ^{[1
]}

Trujillo, Martha E. ^{[3
]}

Saiki, Ikuo ^{[4
]}

Kuwahara, Shigefumi ^{[2
]}

机构：

[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan

[2] Tohoku Univ, Grad Sch Agr Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

[3] Univ Salamanca, Dept Microbiol & Genet, Edificio Dept Lab, Salamanca 37007, Spain

[4] Toyama Univ, Inst Nat Med, Dept Biosci, Toyama 9300194, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 04期

关键词：

ROOT-NODULES; SP NOV;

D O I：

10.1021/np100779t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new anthraquinone derivative, lupinacidin C (1), was isolated from the endophytic actinomycete Micromonospora lupini. The structure was elucidated on the basis of spectroscopic analyses and the absolute configuration was determined by total synthesis. Lupinacidin C (1) exhibitect the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane..

引用

收藏

页码：862 / 865

页数：4

相关论文

共 20 条

[1] Isolation and identification of actinobacteria from surface-sterilized wheat roots [J].

Coombs, JT ;

Franco, CMM .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2003, 69 (09) :5603-5608

[2] Micromonospora pisi sp nov., isolated from root nodules of Pisum sativum [J].

Garcia, Lorena C. ;

Martinez-Molina, Eustoquio ;

Trujillo, Martha E. .

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2010, 60 :331-337

[3] Natural products from plant-associated microorganisms: Distribution, structural diversity, bioactivity, and implications of their occurrence [J].

Gunatilaka, AAL .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (03) :509-526

[4]

Hasegawa S., 2006, Actinomycetologia, V20, P72, DOI DOI 10.3209/SAJ.20.72

[5] Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp nov. [J].

Igarashi, Yasuhiro ;

Trujillo, Martha E. ;

Martinez-Molina, Eustoquio ;

Yanase, Saeko ;

Miyanaga, Satoshi ;

Obata, Takamasa ;

Sakurai, Hiroaki ;

Salki, Ikuo ;

Fujita, Tsuyoshi ;

Furumai, Tamotsu .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (13) :3702-3705

[6] Synthesis of novel antifungal phthalides produced by a wheat rhizosphere fungus [J].

Katoh, Naoto ;

Nakahata, Takashi ;

Kuwahara, Shigefumi .

TETRAHEDRON, 2008, 64 (38) :9073-9077

[7]

Kawamoto I., 1984, Bergey's Manual ofSystematic Bacteriology, P2442

[8]

KOPPENHOEFER B, 1982, SYNTHESIS-STUTTGART, P316

[9] Efficient Synthesis of (2S,3S)-2-Ethyl-3-methylvaleramide Using (1S,2S)-Pseudoephedrine as a Chiral Auxiliary [J].

Li, Bin-Feng ;

Hughes, Robert M. ;

Le, Jackie ;

McGee, Kevin ;

Gallagher, Donald J. ;

Gross, Raymond S. ;

Provencal, David ;

Reddy, Jayachandra P. ;

Wang, Peng ;

Zegelman, Lev ;

Zhao, Yuxin ;

Zook, Scott E. .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2009, 13 (03) :463-467

[10] Diversity of cultivable actinobacteria in geographically widespread marine sediments [J].

Maldonado, LA ;

Stach, JEM ;

Pathom-aree, W ;

Ward, AC ;

Bull, AT ;

Goodfellow, M .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 2005, 87 (01) :11-18