Use of a live attenuated varicella vaccine to boost varicella-specific immune responses in seropositive people 55 years of age and older: Duration of booster effect

被引:123
作者
Levin, MJ
Barber, D
Goldblatt, E
Jones, M
LaFleur, B
Chan, C
Stinson, D
Zerbe, GO
Hayward, AR
机构
[1] Univ Colorado, Sch Med, Dept Pediat, Denver, CO 80262 USA
[2] Univ Colorado, Sch Med, Dept Pediat Infect Dis, Denver, CO 80262 USA
[3] Univ Colorado, Sch Med, Dept Med, Denver, CO 80262 USA
[4] Univ Colorado, Sch Med, Dept Pediat Allergy & Immunol, Denver, CO 80262 USA
[5] Merck Res Labs, W Point, PA USA
关键词
D O I
10.1086/514264
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Varicella-zoster virus (VZV)-specific T cell immunity was measured in 130 persons greater than or equal to 55 years of age 6 years after they received a live attenuated VZV vaccine, Circulating T cells, which proliferated in vitro in response to VZV antigen, were enumerated (VZV responder cell frequency assay). Six years after the booster vaccination, the VZV-responding cell frequency (1/61,000 circulating cells) was still significantly (P < .05) improved over the baseline measurements (1/70,000) and appears to have diminished the expected decline in frequency as these vaccinees aged (to 1/86,000). Ten herpes-tester-like clinical events were recorded. Although the frequency of these events, similar to 1/100 patient-years, is within the expected range of such events for this age cohort, the number of lesions was small, there was very little pain, and there was no postherpetic neuralgia, These results support the development of a vaccine to prevent or attenuate herpes zoster.
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收藏
页码:S109 / S112
页数:4
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