Beclin 1 expression A predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type

被引：66

作者：

Huang, Jia-Jia ^{[1
,2
]}

Li, Hao-Ran ^{[1
,2
]}

Huang, Ying ^{[1
,3
]}

Jiang, Wen-Qi ^{[1
,2
]}

Xu, Rui-Hua ^{[1
,2
]}

Huang, Hui-Qiang ^{[1
,2
]}

Lv, Yue ^{[1
,4
]}

Xia, Zhong-Jun ^{[1
,4
]}

Zhu, Xiao-Feng ^{[1
,2
]}

Lin, Tong-Yu ^{[1
,2
]}

Li, Zhi-Ming ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, State Key Lab Oncol So China, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Dept Radiat Oncol, Guangzhou 510275, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Dept Hematol & Oncol, Guangzhou 510275, Guangdong, Peoples R China

来源：

AUTOPHAGY | 2010年 / 6卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Beclin; 1; extranodal natural killer/T-cell lymphoma; prognosis; overall survival; progression-free survival; HEALTH-ORGANIZATION CLASSIFICATION; AUTOPHAGY; PROTEIN; CANCER; APOPTOSIS; WORKSHOP; DEATH; GENE;

D O I：

10.4161/auto.6.6.12784

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Beclin 1 plays an important role in autophagy, differentiation, antiapoptosis and the development and progression of cancer. The function and expression of Beclin 1 in natural killer T-cell lymphoma is largely unexplored. The study aimed to investigate Beclin 1 expression and its relationship with prognosis in extranodal natural killer T-cell lymphoma, nasal-type (ENKL). Beclin 1 protein expression in 65 tumor specimens from patients newly diagnosed with ENKL was examined by immunohistochemistry (IHC). The clinical significance of Beclin 1 in ENKL was statistically analyzed. Immunopositivity for Beclin 1 was found in 56 (86.2%) of the 65 samples. Low Beclin 1 expression was significantly associated with advanced Ann Arbor stage, intermediate to high IPI risk and elevated LDH level. Low Beclin 1 expression was associated with worse overall survival (OS; p = 0.001) and progression-free survival (PFS; p = 0.017). In multivariate analysis, Beclin 1 expression, advanced Ann Arbor stage and B symptoms were found to be independent prognostic factors of OS and PFS. Consequently, a new clinico-pathological prognostic model was proposed. The model could discriminate different survival outcomes between low risk and high risk groups based on OS and PFS (p < 0.0001, respectively). Beclin 1 expression is predictive of prognosis in ENKL. The new clinico-pathological prognostic model may be help identify patients with different clinical outcomes.

引用

页码：777 / 783

页数：7

共 31 条

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