Beclin 1 expression A predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type

被引:66
作者
Huang, Jia-Jia [1 ,2 ]
Li, Hao-Ran [1 ,2 ]
Huang, Ying [1 ,3 ]
Jiang, Wen-Qi [1 ,2 ]
Xu, Rui-Hua [1 ,2 ]
Huang, Hui-Qiang [1 ,2 ]
Lv, Yue [1 ,4 ]
Xia, Zhong-Jun [1 ,4 ]
Zhu, Xiao-Feng [1 ,2 ]
Lin, Tong-Yu [1 ,2 ]
Li, Zhi-Ming [1 ,2 ]
机构
[1] Sun Yat Sen Univ, State Key Lab Oncol So China, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Dept Radiat Oncol, Guangzhou 510275, Guangdong, Peoples R China
[4] Sun Yat Sen Univ, Dept Hematol & Oncol, Guangzhou 510275, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
Beclin; 1; extranodal natural killer/T-cell lymphoma; prognosis; overall survival; progression-free survival; HEALTH-ORGANIZATION CLASSIFICATION; AUTOPHAGY; PROTEIN; CANCER; APOPTOSIS; WORKSHOP; DEATH; GENE;
D O I
10.4161/auto.6.6.12784
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Beclin 1 plays an important role in autophagy, differentiation, antiapoptosis and the development and progression of cancer. The function and expression of Beclin 1 in natural killer T-cell lymphoma is largely unexplored. The study aimed to investigate Beclin 1 expression and its relationship with prognosis in extranodal natural killer T-cell lymphoma, nasal-type (ENKL). Beclin 1 protein expression in 65 tumor specimens from patients newly diagnosed with ENKL was examined by immunohistochemistry (IHC). The clinical significance of Beclin 1 in ENKL was statistically analyzed. Immunopositivity for Beclin 1 was found in 56 (86.2%) of the 65 samples. Low Beclin 1 expression was significantly associated with advanced Ann Arbor stage, intermediate to high IPI risk and elevated LDH level. Low Beclin 1 expression was associated with worse overall survival (OS; p = 0.001) and progression-free survival (PFS; p = 0.017). In multivariate analysis, Beclin 1 expression, advanced Ann Arbor stage and B symptoms were found to be independent prognostic factors of OS and PFS. Consequently, a new clinico-pathological prognostic model was proposed. The model could discriminate different survival outcomes between low risk and high risk groups based on OS and PFS (p < 0.0001, respectively). Beclin 1 expression is predictive of prognosis in ENKL. The new clinico-pathological prognostic model may be help identify patients with different clinical outcomes.
引用
收藏
页码:777 / 783
页数:7
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