Inhibition of Aldose Reductase In Vitro by Constituents of Ganoderma lucidum

被引：30

作者：

Fatmawati, Sri ^{[1
,2
]}

Shimizu, Kuniyoshi

Kondo, Ryuichiro

机构：

[1] Kyushu Univ, Fac Agr, Dept Forest & Forest Prod Sci, Higashi Ku, Fukuoka 8128581, Japan

[2] Sepuluh Nopember Inst Technol, Fac Math & Nat Sci, Dept Chem, Kampus ITS Sukolilo, Surabaya, Indonesia

来源：

PLANTA MEDICA | 2010年 / 76卷 / 15期

关键词：

Ganoderma lucidum; Ganodermataceae; aldose reductase inhibitor; ganoderic acid; triterpenoid; FR KARST; FRUITING BODIES; SORBINIL; LANOSTANOIDS; APPLANATUM; EXTRACT;

D O I：

10.1055/s-0030-1249782

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

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收藏

页码：1691 / 1693

页数：3

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