Genetic and Antigenic Diversity of Human Rotaviruses: Potential Impact on Vaccination Programs

被引：104

作者：

Kirkwood, Carl D. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Enter Virus Res Grp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Parkville, Vic 3052, Australia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷

基金：

英国医学研究理事会;

关键词：

GROUP-A ROTAVIRUSES; G9; STRAINS; PHYLOGENETIC ANALYSIS; ANTIBODY-RESPONSES; IMMUNE-RESPONSES; UNITED-KINGDOM; HIGH-FREQUENCY; P TYPES; CHILDREN; VP7;

D O I：

10.1086/653548

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The successful development and implementation of rotavirus vaccines will have a significant impact on rotavirus-induced gastroenteritis in children worldwide. However, this introduction will increase the immune pressure against wild-type rotavirus strains circulating in the community, altering the forces and balances that drive rotavirus evolution. There is concern that antigenically distinct novel or rare strains may be selected and spread, decreasing vaccine efficacy. This review describes the diversity of rotavirus strains and the mechanism by which wild-type rotavirus strains can evolve, including genetic drift and genetic reassortment.

引用

收藏

页码：S43 / S48

页数：6

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