NMR structural analysis of epigallocatechin gallate loaded polysaccharide nanoparticles

被引：32

作者：

Peres, Ivone ^{[2
]}

Rocha, Sandra ^{[2
]}

Pereira, Maria do Carmo ^{[2
]}

Coelho, Manuel ^{[2
]}

Rangel, Maria ^{[3
]}

Ivanova, Galya ^{[1
]}

机构：

[1] Univ Porto, Fac Ciencias, Dept Quim, REQUIMTE, P-4169007 Oporto, Portugal

[2] Univ Porto, Fac Engn, Dept Chem Engn, LEPAE, P-4200465 Oporto, Portugal

[3] Univ Porto, REQUIMTE, Inst Ciencias Biomed Abel Salazar, P-4009003 Oporto, Portugal

来源：

CARBOHYDRATE POLYMERS | 2010年 / 82卷 / 03期

关键词：

NMR; DOSY; Relaxation; Epigallocatechin gallate; Polysaccharide nanoparticles; Drug carriers; NUCLEAR-MAGNETIC-RESONANCE; GREEN TEA CATECHIN; DIFFUSION; SPECTROSCOPY; RELAXATION; DIGESTION; DELIVERY; SYSTEMS; CANCER;

D O I：

10.1016/j.carbpol.2010.06.007

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Nuclear magnetic resonance (NMR) spectroscopy has been employed for structural characterization of epigallocatechin gallate loaded maltodextrin/gum arabic nanoparticles (EGCG-MD/GA). Measurements of the nuclear relaxation times (T-1) and application of diffusion ordered spectroscopy (DOSY), obtained through pulsed field gradient (PFG) NMR experiments, have been performed to determine the structure of the epigallocatechin gallate-polysaccharide conjugates and to clarify the mechanisms of drug immobilization into the polymer matrix. The results suggest the entrapment of EGCG into the polysaccharide matrix of maltodextrin/gum arabic (MD/GA) and support the potential of these vehicles for their sustained delivery and release. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：861 / 866

页数：6

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