An Integrated Approach to Diabetic Retinopathy Research

被引：76

作者：

Gardner, Thomas W. ^{[1
,2
]}

Abcouwer, Steven F. ^{[1
,2
,3
]}

Barber, Alistair J. ^{[1
,2
]}

Jackson, Gregory R. ^{[1
]}

机构：

[1] Penn State Coll Med, Dept Ophthalmol, Hershey, PA USA

[2] Penn State Coll Med, Dept Cellular & Mol Physiol, Hershey, PA USA

[3] Penn State Coll Med, Dept Surg, Hershey, PA USA

来源：

ARCHIVES OF OPHTHALMOLOGY | 2011年 / 129卷 / 02期

关键词：

RETINAL INSULIN-RECEPTOR; MICROGLIAL ACTIVATION; VASCULAR-PERMEABILITY; GLIAL REACTIVITY; LAYER THICKNESS; RAT; ABNORMALITIES; DYSFUNCTION; METABOLISM; EXPRESSION;

D O I：

10.1001/archophthalmol.2010.362

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

This review discusses the pathophysiology of diabetic retinopathy related to direct effects of loss of insulin receptor action and metabolic dysregulation on the retina. The resulting sensory neuropathy can be diagnosed by structural and functional tests in patients with mild nonproliferative diabetic retinopathy. Research teams can collaborate to integrate ocular and systemic factors that impair vision and to design strategies to maintain retinal function in persons with diabetes mellitus. Evolving concepts may lead to inclusion of tests of retinal function in the detection of diabetic retinopathy and neuroprotective strategies to preserve vision for persons with diabetes. Arch Ophthalmol. 2011;129(2):230-235

引用

页码：230 / 235

页数：6

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