Imaging Stroke Patients with Unclear Onset Times

被引：26

作者：

Wu, Ona ^{[1
]}

Schwamm, Lee H. ^{[2
,3
]}

Sorensen, A. Gregory ^{[1
]}

机构：

[1] MGH, Dept Radiol, MGH MIT HMS Athinoula Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[2] MGH, Neurol Serv, Boston, MA 02114 USA

[3] MGH, TeleStroke & Acute Stroke Serv, Dept Neurol, Boston, MA 02114 USA

来源：

NEUROIMAGING CLINICS OF NORTH AMERICA | 2011年 / 21卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Stroke; Brain ischemia; Thrombolytic therapy; Diffusion magnetic resonance imaging; Perfusion magnetic resonance imaging; Time; APPARENT DIFFUSION-COEFFICIENT; ACUTE ISCHEMIC-STROKE; CEREBRAL-ARTERY OCCLUSION; DELAYED NEURONAL DEATH; WAKE-UP STROKE; CIRCADIAN VARIATION; THROMBOLYTIC THERAPY; EARLY REPERFUSION; HEMORRHAGIC TRANSFORMATION; TEMPORAL EVOLUTION;

D O I：

10.1016/j.nic.2011.02.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stroke is a leading cause of death and adult morbidity worldwide. By defining stroke symptom onset by the time the patient was last known to be well, many patients whose onsets are unwitnessed are automatically ineligible for thrombolytic therapy. Advanced brain imaging may serve as a substitute witness to estimate stroke onset and duration in those patients who do not have a human witness. This article reviews and compares some of these imaging-based approaches to thrombolysis eligibility, which can potentially expand the use of thrombolytic therapy to a broader population of acute stroke patients.

引用

页码：327 / +

页数：19

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