共 11 条
The great MYC escape in tumorigenesis
被引:84
作者:
Dang, CV
[1
]
O'Donnell, KA
Juopperi, T
机构:
[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Program Pathobiol, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21205 USA
来源:
关键词:
D O I:
10.1016/j.ccr.2005.08.005
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Increased wild-type MYC expression occurs frequently in human cancers, except in Burkitt's lymphoma, where the translocated MYC allele is frequently mutated at several hotspots, including a major one at threonine-58. Acute MYC expression increases p53 or ARF levels and induces apoptosis, and previous transgenic animal studies revealed frequent inactivating mutations of p53 or p19ARF in transgenic Myc-induced lymphomas. Lowe and coworkers (Hemann et al., 2005) demonstrate that wild-type MYC can also trigger apoptosis by inducing Bim, which neutralizes Bcl-2. In contrast, the MYC point mutants failed to induce Bim, promoting murine lymphomas that escaped both wild-type p53 and p19ARF, and in doing so, evaded apoptosis.
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页码:177 / 178
页数:2
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