Functions of DNA methylation: islands, start sites, gene bodies and beyond

被引：4179

作者：

Jones, Peter A. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, USC Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 07期

基金：

美国国家卫生研究院;

关键词：

DE-NOVO METHYLATION; CPG ISLAND; CHROMATIN-STRUCTURE; CYTOSINE METHYLATION; BINDING SITES; 5-HYDROXYMETHYLCYTOSINE; HYPERMETHYLATION; CELLS; DEMETHYLATION; TRANSCRIPTION;

D O I：

10.1038/nrg3230

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA methylation is frequently described as a 'silencing' epigenetic mark, and indeed this function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved genome-scale mapping of methylation, we can evaluate DNA methylation in different genomic contexts: transcriptional start sites with or without CpG islands, in gene bodies, at regulatory elements and at repeat sequences. The emerging picture is that the function of DNA methylation seems to vary with context, and the relationship between DNA methylation and transcription is more nuanced than we realized at first. Improving our understanding of the functions of DNA methylation is necessary for interpreting changes in this mark that are observed in diseases such as cancer.

引用

页码：484 / 492

页数：9

共 100 条

[1] A decade of exploring the cancer epigenome - biological and translational implications [J].

Baylin, Stephen B. ;

Jones, Peter A. .

NATURE REVIEWS CANCER, 2011, 11 (10) :726-734

[2] Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene [J].

Bell, AC ;

Felsenfeld, G .

NATURE, 2000, 405 (6785) :482-485

[3] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[4] PHYSICAL MAPPING ACROSS THE FRAGILE-X - HYPERMETHYLATION AND CLINICAL EXPRESSION OF THE FRAGILE-X SYNDROME [J].

BELL, MV ;

HIRST, MC ;

NAKAHORI, Y ;

MACKINNON, RN ;

ROCHE, A ;

FLINT, TJ ;

JACOBS, PA ;

TOMMERUP, N ;

TRANEBJAERG, L ;

FROSTERISKENIUS, U ;

KERR, B ;

TURNER, G ;

LINDENBAUM, RH ;

WINTER, R ;

PEMBREY, M ;

THIBODEAU, S ;

DAVIES, KE .

CELL, 1991, 64 (04) :861-866

[5] Reprogramming towards pluripotency requires AID-dependent DNA demethylation [J].

Bhutani, Nidhi ;

Brady, Jennifer J. ;

Damian, Mara ;

Sacco, Alessandra ;

Corbel, Stephane Y. ;

Blau, Helen M. .

NATURE, 2010, 463 (7284) :1042-U57

[6] An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection [J].

Boumber, Yanis A. ;

Kondo, Yutaka ;

Chen, Xuqi ;

Shen, Lanlan ;

Guo, Yi ;

Tellez, Carmen ;

Estecio, Marcos R. H. ;

Ahmed, Saira ;

Issa, Jean-Pierre J. .

PLOS GENETICS, 2008, 4 (08)

[7] Uncovering the role of 5-hydroxymethylcytosine in the epigenome [J].

Branco, Miguel R. ;

Ficz, Gabriella ;

Reik, Wolf .

NATURE REVIEWS GENETICS, 2012, 13 (01) :7-13

[8] Dnmt3a is essential for hematopoietic stem cell differentiation [J].

Challen, Grant A. ;

Sun, Deqiang ;

Jeong, Mira ;

Luo, Min ;

Jelinek, Jaroslav ;

Berg, Jonathan S. ;

Bock, Christoph ;

Vasanthakumar, Aparna ;

Gu, Hongcang ;

Xi, Yuanxin ;

Liang, Shoudan ;

Lu, Yue ;

Darlington, Gretchen J. ;

Meissner, Alexander ;

Issa, Jean-Pierre J. ;

Godley, Lucy A. ;

Li, Wei ;

Goodell, Margaret A. .

NATURE GENETICS, 2012, 44 (01) :23-U43

[9] A comparative analysis of DNA methylation across human embryonic stem cell lines [J].

Chen, Pao-Yang ;

Feng, Suhua ;

Joo, Jong Wha Joanne ;

Jacobsen, Steve E. ;

Pellegrini, Matteo .

GENOME BIOLOGY, 2011, 12 (07)

[10] Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells [J].

Chen, Taiping ;

Hevi, Sarah ;

Gay, Frederique ;

Tsujimoto, Naomi ;

He, Timothy ;

Zhang, Bailin ;

Ueda, Yoshihide ;

Li, En .

NATURE GENETICS, 2007, 39 (03) :391-396

← 1 2 3 4 5 6 7 8 9 10 →