Enzyme catalysed formation of (S)-cyanohydrins derived from aldehydes and ketones in a biphasic solvent system

被引：97

作者：

Griengl, H

Klempier, N

Pöchlauer, P

Schmidt, M

Shi, NY

Zabelinskaja-Mackova, AA

机构：

[1] Graz Tech Univ, Inst Organ Chem, Spezialforschungsbereich Biolcatalyse, A-8010 Graz, Austria

[2] DSM Chem Linz, A-4021 Linz, Austria

来源：

TETRAHEDRON | 1998年 / 54卷 / 48期

关键词：

cyanohydrins; enzymes and enzyme reactions; stereospecificity;

D O I：

10.1016/S0040-4020(98)00901-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By employing a vigorously stirred two phase system aqueous buffer/organic solvent and using the hydroxynitrile lyase from Hevea brasiliensis as biocatalyst enantiopure (S)-cyanohydrins from aliphatic, unsaturated, aromatic and heteroaromatic aldehydes and methyl alkyl and methyl phenyl ketones are obtained in high yield and in general 98-99% enantiomeric excess. (C) 1998 Elsevier Science Ltd. AII rights reserved.

引用

页码：14477 / 14486

页数：10