The interplay of biology and technology

被引：16

作者：

Fields, S

机构：

[1] Univ Washington, Howard Hughes Med Inst, Dept Genet, Seattle, WA 98195 USA

[2] Univ Washington, Howard Hughes Med Inst, Dept Med, Seattle, WA 98195 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 18期

关键词：

D O I：

10.1073/pnas.191380098

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Technologies for biological research arise in multiple ways-through serendipity, through inspired insights, and through incremental advances-and they are tightly coupled to progress in engineering. Underlying the complex dynamics of technology and biology are the different motivations of those who work in the two realms. Consideration of how methodologies emerge has implications for the planning of interdisciplinary centers and the training of the next generation of scientists.

引用

页码：10051 / 10054

页数：4

共 16 条

[1]

[Anonymous], 2010, RUZHYA MIKROBY STALI

[2]

BRENNER S, 1974, GENETICS, V77, P71

[3]

Base-calling of automated sequencer traces using phred.: II.: Error probabilities [J].

Ewing, B ;

Green, P .

GENOME RESEARCH, 1998, 8 (03) :186-194

[4]

Consed: A graphical tool for sequence finishing [J].

Gordon, D ;

Abajian, C ;

Green, P .

GENOME RESEARCH, 1998, 8 (03) :195-202

[5]

ANALYTICAL AND MICROPREPARATIVE ULTRAHIGH RESOLUTION OF OLIGONUCLEOTIDES BY POLYACRYLAMIDE-GEL HIGH-PERFORMANCE CAPILLARY ELECTROPHORESIS [J].

GUTTMAN, A ;

COHEN, AS ;

HEIGER, DN ;

KARGER, BL .

ANALYTICAL CHEMISTRY, 1990, 62 (02) :137-141

[6]

Initial sequencing and analysis of the human genome [J].

Lander, ES ;

Int Human Genome Sequencing Consortium ;

Linton, LM ;

Birren, B ;

Nusbaum, C ;

Zody, MC ;

Baldwin, J ;

Devon, K ;

Dewar, K ;

Doyle, M ;

FitzHugh, W ;

Funke, R ;

Gage, D ;

Harris, K ;

Heaford, A ;

Howland, J ;

Kann, L ;

Lehoczky, J ;

LeVine, R ;

McEwan, P ;

McKernan, K ;

Meldrim, J ;

Mesirov, JP ;

Miranda, C ;

Morris, W ;

Naylor, J ;

Raymond, C ;

Rosetti, M ;

Santos, R ;

Sheridan, A ;

Sougnez, C ;

Stange-Thomann, N ;

Stojanovic, N ;

Subramanian, A ;

Wyman, D ;

Rogers, J ;

Sulston, J ;

Ainscough, R ;

Beck, S ;

Bentley, D ;

Burton, J ;

Clee, C ;

Carter, N ;

Coulson, A ;

Deadman, R ;

Deloukas, P ;

Dunham, A ;

Dunham, I ;

Durbin, R ;

French, L .

NATURE, 2001, 409 (6822) :860-921

[7]

HIGH-SPEED DNA SEQUENCING BY CAPILLARY ELECTROPHORESIS [J].

LUCKEY, JA ;

DROSSMAN, H ;

KOSTICHKA, AJ ;

MEAD, DA ;

DCUNHA, J ;

NORRIS, TB ;

SMITH, LM .

NUCLEIC ACIDS RESEARCH, 1990, 18 (15) :4417-4421

[8]

MacBeath G, 2000, SCIENCE, V289, P1760

[9]

SPECIFIC ENZYMATIC AMPLIFICATION OF DNA INVITRO - THE POLYMERASE CHAIN-REACTION [J].

MULLIS, K ;

FALOONA, F ;

SCHARF, S ;

SAIKI, R ;

HORN, G ;

ERLICH, H .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1986, 51 :263-273

[10]

THE UNUSUAL ORIGIN OF THE POLYMERASE CHAIN-REACTION [J].

MULLIS, KB .

SCIENTIFIC AMERICAN, 1990, 262 (04) :56-&

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