Haloperidol treatment decreases nerve growth factor levels in the hypothalamus of adult mice

被引：26

作者：

Alleva, E ^{[1
]}

DellaSeta, D ^{[1
]}

Cirulli, F ^{[1
]}

Aloe, L ^{[1
]}

机构：

[1] CNR,IST NEUROBIOL,ROME,ITALY

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1996年 / 20卷 / 03期

关键词：

CNS; haloperidol; hypothalamus; NGF; stress;

D O I：

10.1016/0278-5846(96)00010-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. In a first study different doses of haloperidol (0.6, 1.2, 2.5, 5, 10, or 20 mg/kg; intraperitoneally) were administered to adult male mice (CD-1 strain) and tested for their ability to induce catalepsy. 2. The minimal haloperidol dose inducing complete catalepsy was found to be the 10 mg/kg dose and selected for the second experiment. 3. Using an immunoenzymatic assay (ELISA) hypothalamic nerve growth factor (NGF) level was measured 20 or 180 min following haloperidol injection (10 mg/kg). 4. Haloperidol treatment decreased NGF levels in mouse hypothalamus and this effect did not differ at the two time points tested. 5. The role of hypothalamic NGF in stress-related events is discussed.

引用

页码：483 / 489

页数：7

共 25 条

[1] PRENATAL HALOPERIDOL TREATMENT DECREASES NERVE GROWTH-FACTOR RECEPTOR AND MESSENGER-RNA IN NEONATE RAT FOREBRAIN [J].