The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor

被引：30

作者：

Hou, YC

Wu, XJ

Xie, WH

Braunschweiger, PG ^{[1
]}

Wang, PG

机构：

[1] Univ Miami, Dept Radiat Oncol, Miami, FL 33136 USA

[2] Wayne State Univ, Dept Chem, Detroit, MI 48201 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(00)02158-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-nitroso-N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased cytotoxicity was observed compared to glucose-7-SNAP and SNAP against DU-145 human prostate cancer cells in vitro. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：825 / 829

页数：5

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