Regulation of cGMP synthesis in photoreceptors: role in signal transduction and congenital diseases of the retina

被引：49

作者：

Dizhoor, AM

机构：

[1] Wayne State Univ, Kresge Eye Inst, Dept Ophthalmol, Detroit, MI 48201 USA

[2] Dept Pharmacol, Detroit, MI 48201 USA

[3] Dept Anat & Cell Biol, Detroit, MI 48201 USA

来源：

CELLULAR SIGNALLING | 2000年 / 12卷 / 11-12期

关键词：

retina; photoreceptor; cGMP; guanylyl cyclase; calcium; GCAP; cone dystrophy;

D O I：

10.1016/S0898-6568(00)00134-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium feedback in vertebrate photoreceptors regulates synthesis of cGMP a second messenger in phototransduction. The decrease in the free intracellular Ca2+ concentrations caused by illumination stimulates two isoforms of retinal membrane guanylyl cyclase (RetGC) via Ca2+-sensor proteins and thus contributes to photoreceptor recovery and light adaptation. Unlike other members of the membrane guanylyl cyclase family, retinal guanylyl cyclases do not have identified extracellular peptide ligands. Recoverin-like proteins, GCAP-1 and GCAP-2, interact with the intracellular portion of the cyclases and stimulate its activity through dimerization of the cyclase subunits. Several mutations that affect the function of photoreceptor guanylyl cyclase and the activator protein have been linked to various farms of congenital human retinal diseases, such as Leber congenital amaurosis, cone and cone-rod dystrophy. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：711 / 719

页数：9

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