Structural basis for the coevolution of a viral RNA-protein complex

被引：184

作者：

Chao, Jeffrey A. ^{[1
]}

Patskovsky, Yury ^{[2
]}

Almo, Steven C. ^{[2
]}

Singer, Robert H. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2008年 / 15卷 / 01期

关键词：

D O I：

10.1038/nsmb1327

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved beta-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.

引用

页码：103 / 105

页数：3

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