Acute exposure to GH during exercise stimulates the turnover of free fatty acids in GH-deficient men

被引:31
作者
Kanaley, JA
Dall, R
Moller, N
Nielsen, SC
Christiansen, JS
Jensen, MD
Jorgensen, JOL
机构
[1] Syracuse Univ, Dept Exercise Sci, Syracuse, NY 13244 USA
[2] Univ Aarhus, Dept Resp Dis, DK-5000 Aarhus, Denmark
[3] Univ Aarhus, Inst Expt Clin Res, DK-5000 Aarhus, Denmark
[4] Univ Aarhus, Med Dept Endocrinol & Diabet M, DK-5000 Aarhus, Denmark
[5] Mayo Clin & Mayo Fdn, Endocrine Res Unit, Rochester, MN 55905 USA
关键词
lipolysis; glucose turnover; protein turnover; growth hormone;
D O I
10.1152/japplphysiol.00711.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The secretion of growth hormone (GH) increases acutely during exercise, but whether this is associated with the concomitant alterations in substrate metabolism has not previously been studied. We examined the effects of acute GH administration on palmitate, glucose, and protein metabolism before, during, and after 45 min of moderate-intensity aerobic exercise in eight GH-deficient men (mean age = 40.8 +/- 2.9 yr) on two occasions, with (+GH; 0.4 IU GH) and without GH administered (-GH). A group of healthy controls (n = 8, mean age = 40.4 +/- 4.2 yr) were studied without GH. The GH replacement during exercise on the +GH study mimicked the endogenous GH profile seen in healthy controls. No significant difference in resting free fatty acid (FFA) flux was found between study days, but during exercise a greater FFA flux was found when GH was administered (211 +/- 26 vs. 168 +/- 28 mumol/min, P < 0.05) and remained elevated throughout recovery ( P < 0.05). With GH administered, the exercise FFA flux was not significantly different from that observed in control subjects (188 +/- 14 mumol/min), but the recovery flux was greater on the +GH day than in the controls ( 169 +/- 17 vs. 119 +/- 11 mumol/min, respectively, P < 0.01). A significant time effect ( P < 0.01) for glucose rate of appearance from rest to exercise and recovery occurred in the GH-deficient adults and the controls, whereas there were no differences in glucose rate of disappearance. No significant effect across time was found for protein muscle balance. In conclusion, 1) acute exposure to GH during exercise stimulates the FFA release and turnover in GH-deficient adults, 2) GH does not significantly impact glucose or protein metabolism during exercise, and 3) the exercise-induced secretion of GH plays a significant role in the regulation of fatty acid metabolism.
引用
收藏
页码:747 / 753
页数:7
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