Click-fluors: Modular fluorescent saccharide sensors based on a 1,2,3-triazole ring

被引:87
作者
Scrafton, David K. [1 ]
Taylor, James E. [1 ]
Mahon, Mary F.
Fossey, John S. [1 ]
James, Tony D. [1 ]
机构
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
关键词
D O I
10.1021/jo702584u
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A carbohydrate sensing "click-fluor" is reported which displays a nontypical binding preference with sample saccharides. That a fluorescent sensor is generated as a result of triazole formation (click reaction), rather than simply bringing the sensor and reporter units together via a triazole linkage, and the potential applicability of the wide range of easily accessible acetylene units means a simple strategy for the development of modular fluorescent sensor arrays for rapid screening of target saccharides will be available.
引用
收藏
页码:2871 / 2874
页数:4
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